In a recently presented research, it is found that one antibody which was made in response to one hemorrhagic fever virus is effective against other related viruses. This comes as a new acheivement given the fact that scientists are facing significant obstacle while developing broad-spectrum antibody-based therapeutics since viruses even from the same family with same molecular make up and receptor binding sites, will end up having substantial degree of variability. The antibody newly created in-vitro in response to one hemorrhagic fever virus can work against other related viruses whose vaccine is yet not discovered.
New stem cells have been discovered by a group of researchers which created two different compartments in mouse lungs and are believed to lead to better lung therapies for lung diseases and injuries. The newly discovered multipotent stem cell once grown and expanded were able to repair the injured tissue and differentiate into many different kinds of cells to make up healthy lung.
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Micro RNA-142-5p Profile as a Predictor of Tumor Markers Regulation in Different Histological Grades of Human Breast Carcinoma
Micro RNA (miRNA) is one of the kinds in non-coding RNA class that regulates gene expression by translational repression, mRNA cleavage, mRNA disruption initiated by miRNA-guided rapid de-adenylation. Up- and/or down-regulated expression study of the miRNA is a good approach to study their function in cancer pathogenesis. In our previous study we understood the down regulation of polycomb gene BMI1 and its correlation with histochemical markers like ER, PR and Her2 in different histological grades of breast tumors. To derive on the identification of regulatory factor accountable for this gene regulation pattern, we tried to identify miRNA that could sway on the gene regulation with the consecutive tumor grades. To adequate this perspective we identified miR-142-5p as a regulating marker for the proliferation of human ductal invasive breast carcinoma using microarray hybridization and attempted to demonstrate the expression profile of miR-142-5p in various histological grades of human breast carcinoma using Real time-PCR amplification. The up regulation of miR-142-5p in histological Grades I, II and III predicted variation with the hormone receptor status. The miR-142-5p up regulation was vice versa with the down regulation of BMI1 gene in the tumors from Grade I to Grade III. Hence with the severity in tumor the up regulated miR-142-5p was estimated to show substantial regulatory effect on expression of the histological markers and polycomb gene BMI1. These signatures shall hold on the diagnosis and therapy for human breast carcinoma.
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Nowadays cancer is one of the main reasons of death all over the world and it is estimated that deaths caused by cancer will grow dramatically in the next decades. Even if chemotherapy is the election therapy for solid tumors, as well as leukemias and lymphomas, cancer treatments are in continuous evolution trying to solve the problem of resistance mainly due to low accumulation of the drug in tumor cells (MDR). Natural compounds represent a valid alternative to treat several disease and recently the scientific community focus on these natural compounds and plant metabolites with therapeutic activities and low toxicities compared with synthetic ones. A combination therapy, that join conventional chemotherapy with natural plant metabolites, is now considered a new promising strategy to overcome MDR and reduce cellular toxicity; in particular, in leukemia due to its very complex origin and development of leukemogenesis. Here, we want to summarize and update the recent applications of natural compounds in the treatment of leukemia.
Axolotl, Mexican salamander (Ambystoma mexicanum) is the most novel biological models used by scientists for almost 150 years to study tissue regeneration due to their ability to several regrow body parts including spinal cord and retinal tissue, scientists have decoded the entire genome of axolotl, largest genome ever sequenced. This study will prove to be most powerful tool for studying tissue regeneration, growing limbs etc.
Keywords: Tissue regeneration, sequencing, genome
The urgent need for new drugs have been increased due to prevalence of antimicrobial-resistant pathogens, however with the recent advancement in genomics and drug discovery many sources from natural products have been found including Actinomycetes which is proving to be a promising source for natural product discovery inspiring many emerging strategies in genomics like actinomycete-derived natural products.
A latest research by a group of neuroscientists investigating which brain area is responsible for storing long term memories have revealed that some odors can trigger memories and experiences from years back. A part of the olfactory brain, ‘piriform cortex’ is able to temporarily store olfactory memories, however, the mechanism works in interaction with other brain areas.
Though piriform cortex works as an archive for long-term memories but it needs instruction from the orbitofrontal cortex – a higher brain area – indicating that an event is to be stored as a long-term memory…