A new drug is helping scientists deliver a new one-two punch that would cure people infected with HIV by using a “shock and kill” concept using the cancer drug Vorinostat. Cells infected with HIV are constantly being killed by medication or the body’s immune system. Some of the cells stop actively producing the virus and go into a dormant state in a “viral reservoir”—but those cells can still reactivate and start producing the virus again. Vorinostat would “shock” the HIV-infected cells awake, bringing the virus out of hiding, which once detected the cells can be “killed”.
Medications can stop HIV from infecting new cells, but doctors haven’t been able to eliminate the disease from the dormant reservoirs, resulting in HIV positive people having to take medication for the rest of their lives. Trials pairing Vorinostat with other HIV drugs are already underway, but the researchers at UNC are finding that the once dormant cells are not being killed by the immune system like other HIV-infected cells. “We do not expect immediate success, but hope to make progress towards the goal of developing treatments that someday might clear HIV infection,” said David Margolis, M.D., director of the UNC HIV Cure Center at the UNC Institute for Global Health & Infectious Diseases.
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Worldwide DNA methylation changes were already announced in leukocytes, and EWAS (epigenome-wide association studies) considers uncovered contrasts in DNA methylation in leukocytes from bladder, head and neck, and ovarian disease, and these distinctions were free of contrasts in white platelet circulation. Differential methylation of 53 CG locales that did not demonstrate proof of relationship with platelet piece was found to connect with ovarian growth hazard in blood DNA. A current report showed relationship between the condition of methylation of different CG site in six qualities and colorectal growth in fringe blood leukocytes and in addition a communication with count calories. An EWAS on 48 coordinated case-controlled matches in a settled case-control examine inside a 22-year follow-up partner of hepatitis B (HepB) transporters uncovered methylation variable positions that were related with movement to HCC and were prescient of the danger of early-beginning HCC a long time before appearance of clinical side effects.
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Identification and #Antibioresistance Characterisation of Culturable #Bacteria in the Intestinal Microbiota of #Mosquitoes
The bacterial microbiota which colonize the mosquito midgut play an important role in vector-parasite interactions and consequently can modulate the level of malaria transmission. Their characterization may contribute to new control strategies of malaria transmission. However, these bacteria may also be eliminated in areas of high antibiotics usage. In this study, we identified paratransgenesis bacteria candidate in the gut of adults female Anopheles in Burkina Faso.
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Systemic Lupus Erythematosus (SLE) is an autoimmune disease of unknown etiology. However, a complex combination of host and environmental factors are believed to play a pivotal role. In the pathogenesis of SLE, several infectious agents have been held responsible such as Cytomegalovirus, Parvovirus B19, Epstein Barr virus and Retrovirus. There is a variable relationship between SLE and Helicobacter, which is different from that of lupus and other infections. The aim of this study was to investigate the association between Helicobacter pylori (H.pylori) infection and SLE development.
Researchers analyzed fecal examples from surfers and non-surfers to evaluate whether the surfers’ guts contained E. coli microscopic organisms that could develop within the sight of the anti-toxin cefotaxime. Cefotaxime has already been endorsed to slaughter off these microscopic organisms, however some have obtained qualities that empower them to survive this treatment. The investigation found that 13 of 143 (9 percent) of surfers were colonized by these safe microorganisms, contrasted with only four of 130 (3 percent) of non-surfers swabbed.
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The examination, by specialists at University of Wisconsin-Madison, the National Park Service and the U.S. Topographical Survey, concentrated on a home assurance program that depended on the intelligent suspicion that imperiled fowls would recreate and thrive if individuals are avoided their homes.
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Breast cancer is one of the leading cancers and the second leading cause of death in women worldwide. It can occur when cancer develops in breast tumor. The tumor tissue has generally higher metabolic and blood perfusion rate than normal tissue. It then causes the temperature rise in the in-vivo breast tissue. Previous researchers have studied the temperature profiles on the breast skin surface only with and without tumor. The aim of the present work is to study the temperature distribution profiles in the layers of breast tissue with and without tumor along the direction from aerola to the body core. Breast tumor can be occurred in any layers of breast tissue but most of the cancer cells are normally developed in glandular layer. So, the study is carried out based on the tumor in glandular layer. Pennes bio-heat equation is used to study the temperature variation in the layers of breast tissue. In the study, it is observed that the location and size of the tumor has significant effect on the breast tissue temperature.
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