Immunology & Microbiology

Pre-Symptomatic Diagnosis of Ebola Virus Infection

Posted on

The epidemic of Ebola virus disease (EVD) that occurred in West Africa during 2013-2014 was a reminder that such outbreaks may continue indefinitely. With the aim of improving diagnosis of EVD early after possible exposure, we worked with data from studies published before the outbreak to ask if changes in the infected host might be assayable within a day of infection, well before the accumulation of viral proteins or nucleic acid which may take several days and on which all existing assays are based. We studied the changes in macaque and human peripheral blood cell gene expression after infection with Zaire Ebolavirus (ZEBOV) to identify host responses that occur before the appearance of indications. We recognised host mRNAs that were differentially communicated at early, middle, and late times after infection.

https://www.scitechnol.com/medical-microbiology-reports.php

 

Hepatitis B Virus Genotype G

Posted on

Hepatitis B virus can be divided into 10 genotypes based on sequence heterogeneity. HBV genotype G (HBV-G) has little genetic variation and often co-exists with another HBV genotype. HBV-G infections have been detected around the world, but rarely from Africa. Over a 9 year period, 3 patients were identified with HBV-G infection while attending a specialist Liver Clinic at a tertiary hospital in Cape Town, South Africa. The aim of this study was to describe the clinical and laboratory features of the patients and sequence the full HBV-G genome to determine the phylogenetic relationship with other HBV-G isolates from around the world. Further, co-infection with other HBV genotypes was determined using a multiplex type- specific PCR and cloning. All patients (2 of Caucasian and 1 of Asian ethnicity) belonged to a high risk group of men who have sex with men and were HBeAg positive. Two patients were co-infected with HIV and HBV co-infection (HBV-A) could only be identified in one case.

Home page: https://www.scitechnol.com/medical-microbiology-reports.php

Age to End Dreadful Diseases (HIV, Malaria, TB, Cancer and More): A Theory of Intact or Protected Complement (IPC) Immunity

Posted on

After enormous efforts to fight for a successful HIV vaccine, the movement ended with frustration. While people are celebrating the victories of disease prophylaxis and health improvement, millions of them are still struggling with numerous unsettled dreadful illnesses, i.e., HIV, malaria, TB, cancer and autoimmune disorders. A theory of Intact or Protected Complement (IPC) immunity proposed in this review is to focus on hijacked complement system, the powerful leverage weapon restrained by many pathogens or cancer cells. The theory is to stimulate more investigations to discover the key block in continuous achievement in successful vaccine development and immune therapy.

Visit us at https://goo.gl/0jl6cb

Submit your manuscript at https://goo.gl/3IDTHt

Rheumatoid arthritis

Posted on Updated on

Rheumatoid arthritis is systemic disease and one of the autoimmune diseases. It is an inflammatory disease in which the cartilage damages and creates pain. This auto immune disease can affect more than joints like other body parts like skin, eyes, lungs, heart, and blood vessels

View Journal update at https://www.scitechnol.com/journal-clinical-immunology-research.php

Mail us your queries or concerns at clinimmunology@journalsoa.org

Follow us at https://twitter.com/ClinicalImmuno1

Inflammatory diseases

Posted on

Inflammatory diseases are the uncontrolled and underlying pathological mechanism of a microbial infection, inflammation is a part of body immune response, it helps in the wound healing. It’s a part of innate immunity and not adaptive immunity. Acute and chronic inflammation are differentiated accordingly on symptoms bases chronic inflammation is the long term inflammation and acute starts rapidly and creates pain, swelling, heat, immobility.

View Journal update at https://www.scitechnol.com/journal-clinical-immunology-research.php

Mail us your queries or concerns at clinimmunology@journalsoa.org

Follow us at https://twitter.com/ClinicalImmuno1

#Mosquitoes can use Smell to See Their Hosts

Posted on

Giving off own their carbon dioxide is one of the ways that attract mosquitoes towards us. It signals dinner-time is here!, A female #mosquito who detects CO2 in the air will buzz around in that area until she traces the wafting gas back to its original source.

For more reading follow us @ http://bit.ly/2vPq6L9

Control of Host Gene Expression by a Herpesvirus Transcription Factor

Posted on

Herpes simplex virus and other alpha-herpesviruses encode a transcription factor, VP16, able to activate expression of genes containing its binding site (TAATGARAT) in the promoter region. VP16 protein is present inside the infectious virion and it enters the host cell with the virus nucleocapsid. Once inside the cell, VP16 is able to cause the prompt expression of virus genes adjacent to its binding sites. I have examined the possibility that host gene expression may have the potential to be affected by the presence of VP16, a situation that could have important effects on alpha-herpesvirus replication. Bioinformatic methods were used to examine five human genome regions (each 16-73Mb in length) for the presence of genes with upstream TAATGARAT sequences. A total of fourteen characterized genes were identified indicating VP16 has the potential to activate their expression. The identified genes varied considerably in function, and did not appear to support a common theme or goal. The presence of an upstream TAATGARAT sequence was found to be well conserved in the homologous genes of chimpanzee where 11 of 14 homologous genes had upstream TAATGARAT’s. Conservation was poor, however, in three other species examined, mouse (2 of 14 genes), horse (2) and chicken (1). The observed pattern of conservation is interpreted to suggest that alpha-herpesviruses evolved the ability to benefit from expression of TAATGARAT-containing host genes and that this process was complete at or before the time chimpanzees and humans diverged evolutionarily (~7Mya).

Read more at http://bit.do/dFpDF