Posted on Updated on

SciTechnol provides space to the advertisers to promote their products/services which lead to successful business.

Founded in 2012, SciTechnol has remained faithful to its commitment to publish world-class, peer-review scientific journals, highly respected by researchers and is organizer of conferences. SciTechnol accomplishes this goal through production and distribution of high caliber electronic and print publications for a broad range of researchers, concentrating on specialists, key opinion leaders and high prescribers. SciTechnol actively solicits advertising and sponsorships in relation to its online and print publications. It is in the best interests of SciTechnol, its advertisers and sponsors to ensure that the products remain a trusted, credible source of information for researchers and other information.

For more information please visit



Micro RNA-142-5p Profile as a Predictor of Tumor Markers Regulation in Different Histological Grades of Human Breast Carcinoma

Posted on Updated on

Micro RNA (miRNA) is one of the kinds in non-coding RNA class that regulates gene expression by translational repression, mRNA cleavage, mRNA disruption initiated by miRNA-guided rapid de-adenylation. Up- and/or down-regulated expression study of the miRNA is a good approach to study their function in cancer pathogenesis. In our previous study we understood the down regulation of polycomb gene BMI1 and its correlation with histochemical markers like ER, PR and Her2 in different histological grades of breast tumors. To derive on the identification of regulatory factor accountable for this gene regulation pattern, we tried to identify miRNA that could sway on the gene regulation with the consecutive tumor grades. To adequate this perspective we identified miR-142-5p as a regulating marker for the proliferation of human ductal invasive breast carcinoma using microarray hybridization and attempted to demonstrate the expression profile of miR-142-5p in various histological grades of human breast carcinoma using Real time-PCR amplification. The up regulation of miR-142-5p in histological Grades I, II and III predicted variation with the hormone receptor status. The miR-142-5p up regulation was vice versa with the down regulation of BMI1 gene in the tumors from Grade I to Grade III. Hence with the severity in tumor the up regulated miR-142-5p was estimated to show substantial regulatory effect on expression of the histological markers and polycomb gene BMI1. These signatures shall hold on the diagnosis and therapy for human breast carcinoma.

Related articles at: Journal of Molecular Biology and Methods

Contact us:



Posted on

SciTechnol is an online publisher that enjoys global presence with International Journals on Clinical, Medical, Environmental, Pharmaceutical, Neurosciences, Environmental Science, and Business Management. SciTechnol offers a meaningful platform to the global scientific community to discuss and share knowledge while disseminating research findings globally.

The mission of SciTechnol is to take the high quality research work close to a wide range of academic and scientific communities.

SciTechnol offers a prompt and efficient review process that enhances the quality of the publication. The ultimate goal of SciTechnol is to aid the scientific community with periodicals focusing on

  • Scientific discoveries
  • Providing data to further research and documentation.

We strive to offer world class service that enables our authors to increase their research impact and reputation.

Our Features

  • 104 Hybrid Access online Journals
  • Online Submission System
  • Quality review process through Editorial Manager
  • 1500 Editorial team
  • 2 Million readers
  • Social Networking -More than 50,000 Facebook Likes
  • Fast Publication Process
  • Audio Conversion Enhanced Feature
  • Digital Articles